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The present study tested a conceptual model of the relationships among religious well-being, existential well-being, positive religious coping, and family protective factors. A sample of three hundred and eighty nine voluntary and unpaid Muslim participants (230 females, 159 males), aged between 21 and 47 years old (31.18 ± 4.28 years), were selected through multi-stage cluster sampling in Isfahan, Iran. All participants were asked to complete the Spiritual Well-Being Scale (SWBS__AWT_NOKT_COMMA__ Paloutzian & Ellison, 1982), the Brief Religious Coping Scale (RCOPE__AWT_NOKT_COMMA__ Pargament, Smith, Koenig, & Perez, 1998), and the Inventory of Family Protective Factors (IFPF__AWT_NOKT_COMMA__ Gardner, Huber, Steiner, Vasquez & Savage, 2008). Using structural equation modeling, the results supported the mediating effects for existential well-being and positive religious coping among religious well-being and family protective factors. The analytic model explained 40% of the distribution of family protective factors. These findings suggest that the positive impact of religious well-being is correlated with family protective factors.